Spectral properties of random matrices play an important role in statistics, machine learning, communications, and many other areas. Engaging results regarding the convergence of the empirical spectral distribution (ESD) and the ``no-eigenvalue'' property have been obtained for random matrices with different correlation structures. However, the related spectral analysis for generally correlated and noncentral random matrices is still incomplete, and this paper aims to fill this research gap. Specifically, we consider matrices whose columns are independent but with non-zero means and non-identical correlations. Under high-dimensional asymptotics where both the number of rows and columns grow simultaneously to infinity, we first establish the almost sure convergence of the ESD for the concerned random matrices to a deterministic limit, assuming mild conditions. Furthermore, we prove that with probability 1, no eigenvalues will appear in any closed interval outside the support of the limiting distribution for matrices with sufficiently large dimensions. The above results can be applied to different areas such as statistics, wireless communications, and signal processing. In this paper, we apply the derived results to two communication scenarios: 1) We determine the limiting performance of the signal-to-interference-plus-noise ratio for multi-user multiple-input multiple-output (MIMO) systems with linear minimum mean-square error receivers; and 2) We establish the invertibility of zero-forcing precoding matrices in downlink MIMO systems, providing theoretical guarantees.