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Exact-corrected confidence interval for risk difference i...
Nour Hawila, Arthur Berg · 2021-04-10 · via math.ST updates on arXiv.org

A novel confidence interval estimator is proposed for the risk difference in noninferiority binomial trials. The confidence interval is consistent with an exact unconditional test that preserves the type-I error, and has improved power, particularly for smaller sample sizes, compared to the confidence interval by Chan & Zhang (1999). The improved performance of the proposed confidence interval is theoretically justified and demonstrated with simulations and examples. An R package is also distributed that implements the proposed methods along with other confidence interval estimators.