We consider a high-dimensional dynamic pricing problem under non-stationarity, where a firm sells products to $T$ sequentially arriving consumers that behave according to an unknown demand model with potential changes at unknown times. The demand model is assumed to be a high-dimensional generalized linear model (GLM), allowing for a feature vector in $\mathbb R^d$ that encodes products and consumer information. To achieve optimal revenue (i.e., least regret), the firm needs to learn and exploit the unknown GLMs while monitoring for potential change-points. To tackle such a problem, we first design a novel penalized likelihood-based online change-point detection algorithm for high-dimensional GLMs, which is the first algorithm in the change-point literature that achieves optimal minimax localization error rate for high-dimensional GLMs. A change-point detection assisted dynamic pricing (CPDP) policy is further proposed and achieves a near-optimal regret of order $O(s\sqrt{Υ_T T}\log(Td))$, where $s$ is the sparsity level and $Υ_T$ is the number of change-points. This regret is accompanied with a minimax lower bound, demonstrating the optimality of CPDP (up to logarithmic factors). In particular, the optimality with respect to $Υ_T$ is seen for the first time in the dynamic pricing literature, and is achieved via a novel accelerated exploration mechanism. Extensive simulation experiments and a real data application on online lending illustrate the efficiency of the proposed policy and the importance and practical value of handling non-stationarity in dynamic pricing.