Let $X_1,\dots,X_n$ be independent nonnegative random variables (r.v.'s), with $S_n:=X_1+\dots+X_n$ and finite values of $s_i:=E X_i^2$ and $m_i:=E X_i>0$. Exact upper bounds on $E f(S_n)$ for all functions $f$ in a certain class $\mathcal{F}$ of nonincreasing functions are obtained, in each of the following settings: (i) $n,m_1,\dots,m_n,s_1,\dots,s_n$ are fixed; (ii) $n$, $m:=m_1+\dots+m_n$, and $s:=s_1+\dots+s_n$ are fixed; (iii)~only $m$ and $s$ are fixed. These upper bounds are of the form $E f(η)$ for a certain r.v. $η$. The r.v. $η$ and the class $\mathcal{F}$ depend on the choice of one of the three settings. In particular, $(m/s)η$ has the binomial distribution with parameters $n$ and $p:=m^2/(ns)$ in setting (ii) and the Poisson distribution with parameter $λ:=m^2/s$ in setting (iii). One can also let $η$ have the normal distribution with mean $m$ and variance $s$ in any of these three settings. In each of the settings, the class $\mathcal{F}$ contains, and is much wider than, the class of all decreasing exponential functions. As corollaries of these results, optimal in a certain sense upper bounds on the left-tail probabilities $P(S_n\le x)$ are presented, for any real $x$. In fact, more general settings than the ones described above are considered. Exact upper bounds on the exponential moments $E\exp\{hS_n\}$ for $h<0$, as well as the corresponding exponential bounds on the left-tail probabilities, were previously obtained by Pinelis and Utev. It is shown that the new bounds on the tails are substantially better.