To successfully work on variable selection, sparse model structure has become a basic assumption for all existing methods. However, this assumption is questionable as it is hard to hold in most of cases and none of existing methods may provide consistent estimation and accurate model prediction in nons-parse scenarios. In this paper, we propose semiparametric re-modeling and inference when the linear regression model under study is possibly non-sparse. After an initial working model is selected by a method such as the Dantzig selector adopted in this paper, we re-construct a globally unbiased semiparametric model by use of suitable instrumental variables and nonparametric adjustment. The newly defined model is identifiable, and the estimator of parameter vector is asymptotically normal. The consistency, together with the re-built model, promotes model prediction. This method naturally works when the model is indeed sparse and thus is of robustness against non-sparseness in certain sense. Simulation studies show that the new approach has, particularly when $p$ is much larger than $n$, significant improvement of estimation and prediction accuracies over the Gaussian Dantzig selector and other classical methods. Even when the model under study is sparse, our method is also comparable to the existing methods designed for sparse models.