A notion of generalized $n$-semimodularity is introduced, which extends that of (sub/super)mod\-ularity in four ways at once. The main result of this paper, stating that every generalized $(n\colon\!2)$-semimodular function on the $n$th Cartesian power of a distributive lattice is generalized $n$-semimodular, may be considered a multi/infinite-dimensional analogue of the well-known Muirhead lemma in the theory of Schur majorization. This result is also similar to a discretized version of the well-known theorem due to Lorentz, which latter was given only for additive-type functions. Illustrations of our main result are presented for counts of combinations of faces of a polytope; one-sided potentials; multiadditive forms, including multilinear ones -- in particular, permanents of rectangular matrices and elementary symmetric functions; and association inequalities for order statistics. Based on an extension of the FKG inequality due to Rinott \& Saks and Aharoni \& Keich, applications to correlation inequalities for order statistics are given as well.