Quantum state tomography (QST), the process of reconstructing some unknown quantum state $\hatρ$ from repeated measurements on copies of said state, is a foundationally important task in the context of quantum computation and simulation. For this reason, a detailed characterization of the error $Δ\hatρ= \hatρ-\hatρ^\prime$ in a QST reconstruction $\hatρ^\prime$ is of clear importance to quantum theory and experiment. In this work, we develop a fully random matrix theory (RMT) treatment of state tomography in informationally-complete bases; and in doing so we reveal deep connections between QST errors $Δ\hatρ$ and the gaussian unitary ensemble (GUE). By exploiting this connection we prove that wide classes of functions of the spectrum of $Δ\hatρ$ can be evaluated by substituting samples of an appropriate GUE for realizations of $Δ\hatρ$. This powerful and flexible result enables simple analytic treatments of the mean value and variance of the error as quantified by the trace distance $\|Δ\hatρ\|_\mathrm{Tr}$ (which we validate numerically for common tomographic protocols), allows us to derive a bound on the QST sample complexity, and subsequently demonstrate that said bound doesn't change under the most widely-used rephysicalization procedure. These results collectively demonstrate the flexibility, strength, and broad applicability of our approach; and lays the foundation for broader studies of RMT treatments of QST in the future.