This paper establishes a quantitative, uniform-in-time diffusion approximation for the joint law of a broad class of fully coupled multiscale stochastic systems. We derive a precise characterization of the limiting joint distribution as a specific skew-product of the conditional equilibrium of the fast process and the homogenized law of the slow component, thereby providing a rigorous uniform-in-time formulation of the adiabatic elimination principle. The convergence rate explicitly separates the initial relaxation of the fast dynamics from the long-time homogenized evolution and depends only on the regularity of the coefficients in the slow variable. As a consequence, we obtain the first quantitative identification of the limiting stationary distribution of the original multiscale system and prove the commutativity of the limits $\eps\to0$ and $t\to\infty$ for a large class of observables. Our framework accommodates unbounded and irregular coefficients, degenerate structures, and weakly mixing dynamics. We illustrate its scope with three applications: {\it (i)} a uniform-in-time averaging principle for fast-slow systems; {\it (ii)} a uniform Smoluchowski--Kramers approximation for degenerate Langevin systems, yielding convergence of the joint position-scaled velocity law and global-in-time asymptotics of key thermodynamic functionals (e.g., total energy, entropy production, free energy); and {\it (iii)} the first uniform-in-time periodic homogenization result for SDEs with distributional drifts.