This paper introduces a framework of Constrained Mean-Field Games (CMFGs), where each agent solves a constrained Markov decision process (CMDP). This formulation captures scenarios in which agents' strategies are subject to feasibility, safety, or regulatory restrictions, thereby extending the scope of classical mean field game (MFG) models. We first establish the existence of CMFG equilibria under a strict feasibility assumption, and we further show uniqueness under a classical monotonicity condition. To compute equilibria, we develop Constrained Mean-Field Occupation Measure Optimization (CMFOMO), an optimization-based scheme that parameterizes occupation measures and shows that finding CMFG equilibria is equivalent to solving a single optimization problem with convex constraints and bounded variables. CMFOMO does not rely on uniqueness of the equilibria and can approximate all equilibria with arbitrary accuracy. We further prove that CMFG equilibria induce $O(1 / \sqrt{N})$-Nash equilibria in the associated constrained $N$-player games, thereby extending the classical justification of MFGs as approximations for large but finite systems. Numerical experiments on a modified Susceptible-Infected-Susceptible (SIS) epidemic model with various constraints illustrate the effectiveness and flexibility of the framework.