This paper investigates a non-autonomous slow-fast system, which is generalized by stochastic differential equations (SDEs) with locally Lipschitz coefficients, subjected to standard Brownian motion (Bm) and fractional Brownian motion (fBm) with Hurst parameter 1/2<H<1. We concentrate on how to handle both types of integrals with respect to Bm and fBm and the locally Lispchitz continuity. The pathwise approach and the Ito stochastic calculus are combined with the technique of stopping time to establish the averaging principle where the averaged equation is defined. Then, the slow component of the original slow-fast system converges to the solution of the proposed averaged equation in the mean square sense is verified.