We consider a gas of N particles with a general two-body interaction and confined by an external potential in the mean field or high temperature regime, that is when the inverse temperature satisfies $βN \to κ\ge 0$ as $N\to+\infty$. We show that under general conditions on the interaction and the potential, the local fluctuations are described by a Poisson point process in the large N limit. We present applications to Coulomb and Riesz gases on $\mathbb{R}^n$ for any $n\ge 1$, as well as to the edge behavior of $β$-ensembles on $\mathbb{R}$.