We introduce a framework, which is a mesoscopic-fluctuation-scale analog of Yau's method [46] for hydrodynamic limits, for deriving KPZ equations with time-dependent coefficients from time-inhomogeneous interacting particle systems. To our knowledge, this is the first derivation of a time-inhomogeneous KPZ equation whose solution theory has an additional nonlinearity that is absent in the time-homogeneous case. So, we also show global well-posedness for the SPDE. To be concrete, we restrict to time-inhomogeneous Ginzburg-Landau SDEs. The method for deriving KPZ is based on a Cole-Hopf transform, whose analysis is the bulk of this paper. The key ingredient for said analysis is a ``local" second-order Boltzmann-Gibbs principle, shown by stochastic calculus of the Ginzburg-Landau SDEs and regularity estimates for their Kolmogorov equations, all of which likely generalizes to many other particle systems. This addresses a ``Big Picture Question" in [47] on deriving KPZ equations. It is also, to our knowledge, a first result on KPZ-type limits in a non-equilibrium like that in [6].