In this paper, we prove the edge universality of largest eigenvalues for separable covariance matrices of the form $\mathcal Q :=A^{1/2}XBX^*A^{1/2}$. Here $X=(x_{ij})$ is an $n\times N$ random matrix with $x_{ij}=N^{-1/2}q_{ij}$, where $q_{ij}$ are $i.i.d.$ random variables with zero mean and unit variance, and $A$ and $B$ are respectively $n \times n$ and $N\times N$ deterministic non-negative definite symmetric (or Hermitian) matrices. We consider the high-dimensional case, i.e. ${n}/{N}\to d \in (0, \infty)$ as $N\to \infty$. Assuming $\mathbb E q_{ij}^3=0$ and some mild conditions on $A$ and $B$, we prove that the limiting distribution of the largest eigenvalue of $\mathcal Q$ coincide with that of the corresponding Gaussian ensemble (i.e. the $\mathcal Q$ with $X$ being an $i.i.d.$ Gaussian matrix) as long as we have $\lim_{s \rightarrow \infty}s^4 \mathbb{P}(\vert q_{ij} \vert \geq s)=0$, which is a sharp moment condition for edge universality. If we take $B=I$, then $\mathcal Q$ becomes the normal sample covariance matrix and the edge universality holds true without the vanishing third moment condition. So far, this is the strongest edge universality result for sample covariance matrices with correlated data (i.e. non-diagonal $A$) and heavy tails, which improves the previous results in \cite{BPZ1,LS} (assuming high moments and diagonal $A$), \cite{Anisotropic} (assuming high moments) and \cite{DY} (assuming diagonal $A$).