In this paper, we establish the ergodicity for stochastic 2D Navier-Stokes equations driven by a highly degenerate pure jump Lévy noise. The noise could appear in as few as four directions. This gives an affirmative anwser to a longstanding problem. The case of Gaussian noise was treated in Hairer and Mattingly [\emph{Ann. of Math.}, 164(3):993--1032, 2006]. To obtain the uniqueness of invariant measure, we use Malliavin calculus and anticipating stochastic calculus to establish the equi-continuity of the semigroup, the so-called {\em e-property}, and prove some weak irreducibility of the solution process.