We investigate the application of the Adaptive Multilevel Splitting algorithm for the estimation of tail probabilities of solutions of Stochastic Differential Equations evaluated at a given time, and of associated temporal averages. We introduce a new, very general and effective family of score functions which is designed for these problems. We illustrate its behavior on a series of numerical experiments. In particular, we demonstrate how it can be used to estimate large deviation rate functionals for the longtime limit of temporal averages.