In this paper, we establish the locally diffeomorphic property of the solution to McKean-Vlasov stochastic differential equations defined on the Euclidean space. Our approach is built upon the insightful ideas put forth by Kunita. We observe that although the coefficients satisfy the global Lipschitz condition and some suitable regularity condition, the solution in general does not satisfy the globally homeomorphic property at any time except the initial time, which sets McKean-Vlasov stochastic differential equations apart significantly from classical stochastic differential equations. Finally, we provide an example to complement our results.