How should we schedule jobs to minimize mean queue length? In the preemptive M/G/1 queue, we know the optimal policy is the Gittins policy, which uses any available information about jobs' remaining service times to dynamically prioritize jobs. For models more complex than the M/G/1, optimal scheduling is generally intractable. This leads us to ask: beyond the M/G/1, does Gittins still perform well? Recent results show Gittins performs well in the M/G/k, meaning that its additive suboptimality gap is bounded by an expression which is negligible in heavy traffic. But allowing multiple servers is just one way to extend the M/G/1, and most other extensions remain open. Does Gittins still perform well with non-Poisson arrival processes? Or if servers require setup times when transitioning from idle to busy? In this paper, we give the first analysis of the Gittins policy that can handle any combination of (a) multiple servers, (b) non-Poisson arrivals, and (c) setup times. Our results thus cover the G/G/1 and G/G/k, with and without setup times, bounding Gittins's suboptimality gap in each case. Each of (a), (b), and (c) adds a term to our bound, but all the terms are negligible in heavy traffic, thus implying Gittins's heavy-traffic optimality in all the systems we consider. Another consequence of our results is that Gittins is optimal in the M/G/1 with setup times at all loads.