We consider random walks on marked simple point processes with symmetric jump rates and unbounded jump range. We prove homogenization properties of the associated Markov generators. As an application, we derive the hydrodynamic limit of the simple exclusion process given by multiple random walks as above, with hard-core interaction, on a marked Poisson point process. The above results cover Mott variable range hopping, which is a fundamental mechanism of phonon-induced electron conduction in amorphous solids as doped semiconductors. Our techniques, based on an extension of two-scale convergence, can be adapted to other models, as e.g. the random conductance model.