For a multivariate Lévy process satisfying the Cramér moment condition and having a drift vector with at least one negative component, we derive the exact asymptotics of the probability of ever hitting the positive orthant that is being translated to infinity along a fixed vector with positive components. This problem is motivated by the multivariate ruin problem introduced in F. Avram et al. (2008) in the two-dimensional case. Our solution relies on the analysis from Y. Pan and K. Borovkov (2017) for multivariate random walks and an appropriate time discretization.