In this paper, we establish ergodic and mixing properties of stochastic 2D Navier-Stokes equations driven by a highly degenerate multiplicative Gaussian noise. The noise could appear in as few as four directions and the intensity of the noise depends on the solution. The case of additive Gaussian noise was treated in Hairer and Mattingly [\emph{Ann. of Math.}, 164(3):993--1032, 2006]. To obtain ergodic and mixing properties, we use Malliavin calculus to establish the asymptotically strong Feller property. The main difficulty lies in the proof of the "invertibility" of Malliavin matrix which is totally different from the additive case.