We study the smoothness of the solution of the directed chain stochastic differential equations, where each process is affected by its neighborhood process in an infinite directed chain graph, introduced by Detering et al. (2020). Because of the auxiliary process in the chain-like structure, classic methods of Malliavin derivatives are not directly applicable. Namely, we cannot make a connection between the Malliavin derivative and the first order derivative of the state process. It turns out that the partial Malliavin derivatives can be used here to fix this problem.