We study Dyson Brownian motion with general potential $V$ and for general $β\geq 1$. For short times $t = o (1)$ and under suitable conditions on $V$ we obtain a local law and corresponding rigidity estimates on the particle locations; that is, with overwhelming probability, the particles are close to their classical locations with an almost-optimal error estimate. Under the condition that the density of states of the initial data is bounded below and above down to the scale $η_* \ll t \ll 1$, we prove a mesoscopic central limit theorem for linear statistics at all scales $N^{-1}\llη\ll t$