We derive an asymptotic log-Harnack inequality for nonlinear monotone SPDE driven by possibly degenerate multiplicative noise. Our main tool is the asymptotic coupling by the change of measure. As an application, we show that, under certain monotone and coercive conditions on the coefficients, the corresponding Markov semigroup is asymptotically strong Feller, asymptotic irreducibility, and possesses a unique and thus ergodic invariant measure. The results are applied to highly degenerate finite-dimensional or infinite-dimensional diffusion processes.