In this article we study the differentiability of solutions of parabolic semilinear stochastic evolution equations (SEEs) with respect to their initial values. We prove that if the nonlinear drift coefficients and the nonlinear diffusion coefficients of the considered SEEs are $n$-times continuously Fréchet differentiable, then the solutions of the considered SEEs are also $n$-times continuously Fréchet differentiable with respect to their initial values. Moreover, a key contribution of this work is to establish suitable enhanced regularity properties of the derivative processes of the considered SEE in the sense that the dominating linear operator appearing in the SEE smoothes the higher order derivative processes.