We consider the problem of quantum and stochastic confinement for drift-diffusion equations on domains $ Ω\subset \mathbb R^d$. We obtain various sufficient conditions on the behavior of the coefficients near the boundary of $Ω$ which ensure the essential self-adjointness or stochastic completeness of the symmetric form of the drift-diffusion operator, $-\frac{1}{ρ_\infty}\,\nabla\cdot ρ_\infty\mathbb D\nabla$. The proofs are based on the method developed in [29] for quantum confinement on bounded domains in $\mathbb R^d$. In particular for stochastic confinement we combine the Liouville property with Agmon type exponential estimates for weak solutions.