In this paper we consider an SPDE where the leading term is a second order operator with periodic boundary conditions, coefficients which are measurable in $(t,ω)$, and Hölder continuous in space. Assuming stochastic parabolicity conditions, we prove $L^p((0,T)\times Ω, t^κ\, \mathrm{d} t;H^{σ,q}(\mathbb{T}^d))$-estimates. The main novelty is that we do not require $p=q$. Moreover, we allow arbitrary $σ\in \mathbb{R}$ and weights in time. Such mixed regularity estimates play a crucial role in applications to nonlinear SPDEs which is clear from our previous work. To prove our main results we develop a general perturbation theory for SPDEs. Moreover, we prove a new result on pointwise multiplication in spaces with fractional smoothness.