We establish strong Feller property and irreducibility for the transition semigroup associated to a class of nonlinear stochastic partial differential equations with multiplicative degenerate noise. As a by-product, we prove uniqueness of the invariant measure under no strong-dissipativity assumptions. The drift of the equation diverges exactly where the noise coefficient vanishes, resulting in a competition between the dissipative effects and the degeneracy of the noise. We propose a method to measure the accumulation of the solution towards the potential barriers, allowing to give rigorous meaning to the inverse of the degenerate noise coefficient. From the mathematical perspective, this is one of the first contributions in the literature establishing strong Feller properties and irreducibility in the multiplicative degenerate case, and opens up novel investigation paths in the direction of regularisation effects and ergodicity in the degenerate-noise framework. From the application perspective, the models cover interesting scenarios in physics, in the context of evolution of relative concentrations of mixtures, under the influence of thermodynamically-relevant potentials of Flory-Huggins type.