Modern methods of simulating molecular systems are based on the mathematical theory of Markov operators with a focus on autonomous equilibrated systems. However, non-autonomous physical systems or non-autonomous simulation processes are becoming more and more important. We present a representation of non-autonomous Markov jump processes as autonomous Markov chains on space-time. Augmenting the spatial information of the embedded Markov chain by the temporal information of the associated jump times, we derive the so-called augmented jump chain. The augmented jump chain inherits the sparseness of the infinitesimal generator of the original process and therefore provides a useful tool for studying time-dependent dynamics even in high dimensions. We furthermore discuss possible generalizations and applications to the computation of committor functions and coherent sets in the non-autonomous setting. After deriving the theoretical foundations we illustrate the concepts with a proof-of-concept Galerkin discretization of the transfer operator of the augmented jump chain applied to simple examples.