We study probability measures on partitions based on symmetric Grothendieck polynomials. These deformations of Schur polynomials introduced in the K-theory of Grassmannians share many common properties. Our Grothendieck measures are analogs of the Schur measures on partitions introduced by Okounkov (arXiv:math/9907127 [math.RT]). Despite the similarity of determinantal formulas for the probability weights of Schur and Grothendieck measures, we demonstrate that Grothendieck measures are \emph{not} determinantal point processes. This question is related to the principal minor assignment problem in algebraic geometry, and we employ a determinantal test first obtained by Nanson in 1897 for the $4\times4$ problem. We also propose a procedure for getting Nanson-like determinantal tests for matrices of any size $n\ge4$ which appear new for $n\ge 5$. By placing the Grothendieck measures into a new framework of tilted biorthogonal ensembles generalizing a rich class of determinantal processes introduced by Borodin (arXiv:math/9804027 [math.CA]), we identify Grothendieck random partitions as a cross-section of a Schur process, a determinantal process in two dimensions. This identification expresses the correlation functions of Grothendieck measures through sums of Fredholm determinants, which are not immediately suitable for asymptotic analysis. A more direct approach allows us to obtain a limit shape result for the Grothendieck random partitions. The limit shape curve is not particularly explicit as it arises as a cross-section of the limit shape surface for the Schur process. The gradient of this surface is expressed through the argument of a complex root of a cubic equation.