A generalization of the Sherrington-Kirkpatrick (SK) model for spin glasses is considered, in which the interaction matrix is endowed with a variance profile that has no particular structure an may be sparse. In the first part of this paper, an asymptotic equivalent of the free energy is derived at sufficiently high temperatures, regardless of the signature of the variance profile matrix. In the second part, the mean of the spin vector under the Gibbs measure is estimated using an Approximate Message Passing algorithm based on the Thouless-Anderson-Palmer equations. The dynamical approach of Adhikari et.al. (J. Stat. Phys., 2021), originally developed for the classical SK model, is adapted to the present setting to obtain these results.