Statistical mechanics explains the properties of macroscopic phenomena based on the movements of microscopic particles such as atoms and molecules. Movements of microscopic particles can be represented by large-scale interacting systems. In this article, we study a combinatorial object which we call interactions, given as a symmetric directed graph representing the possible transition of states on adjacent sites of large-scale interacting systems. Such interactions underlie various standard processes such as the exclusion processes, generalized exclusion processes, multi-species exclusion processes, lattice-gas processes with energy, and the multi-lane particle processes. We introduce the notion of equivalences of interactions using their space of conserved quantities. This allows for the classification of interactions reflecting corresponding macroscopic properties. In particular, we prove that when the set of local states consists of two, three or four elements, then the number of equivalence classes of separable interactions are respectively one, two and five. We also define the wedge sums and box products of interactions, which give systematic methods for constructing new interactions from existing ones. Furthermore, we prove that the irreducibly quantified condition for interactions, which has implicitly played an important role in the theory of hydrodynamic limits, is preserved by wedge sums and box products. Our results provide a systematic method to construct and classify interactions, offering abundant examples suitable for considering hydrodynamic limits.