Many science phenomena are described as interacting particle systems (IPS). The mean field limit (MFL) of large all-to-all coupled deterministic IPS is given by the solution of a PDE, the Vlasov Equation (VE). Yet, many applications demand IPS coupled on networks/graphs. It is interesting to know, how the limit of a sequence of digraphs associated with the IPS influences the macroscopic MFL. This paper studies VEs on a generalized digraph, regarded as limit of a sequence of digraphs, which we refer to as a digraph measure (DGM) to emphasize that we work with its limit via measures. We provide well-posedness and discretization of the solution of the VE by empirical distributions supported on solutions of an IPS via ODEs coupled on a sequence of digraphs converging to the given DGM. Our result extends existing results on one-dimensional Kuramoto-type networks coupled on dense graphs. Here we allow the underlying digraphs to be not necessarily dense which include many interesting graphical structures such that stars, trees and rings, which have been frequently used in many sparse network models in finance, telecommunications, physics, genetics, neuroscience, and social sciences. A key contribution of this paper is a nontrivial generalization of Neunzert's in-cell-particle approach for all-to-all coupled indistinguishable IPS with global Lipschitz continuity in Euclidean spaces to distinguishable IPS on heterogeneous digraphs with local Lipschitz continuity, via a measure-theoretic viewpoint. The approach together with the metrics is different from the known techniques in $L^p$-functions using graphons and their generalization via harmonic analysis of locally compact Abelian groups. Finally, to demonstrate the wide applicability, we apply our results to various models in higher-dimensional Euclidean spaces in epidemiology, ecology, and social sciences.