In 1993 van den Berg and Kesten proved a strict monotonicity theorem for first passage percolation on $\mathbb{Z}^d$, $d \ge 2$: given two probability measures $ν$ and $\tildeν$ with finite mean, if $\tildeν$ is strictly more variable than $ν$ and $ν$ is subcritical in an appropriate sense, the time constant associated to $\tildeν$ is strictly smaller than the time constant associated to $ν$. In this paper, an analogous result is proven for (not necessarily almost-transitive) graphs of strict polynomial growth and for bounded degree graphs quasi-isometric to trees which satisfy a certain geometric condition we call "admitting detours." It is also proven that if a bounded degree graph does not admit detours, then such a strict monotonicity theorem with respect to variability cannot hold. Large classes of graphs are shown to admit detours, and we conclude that for example any Cayley graph of a virtually nilpotent group which is not isomorphic to the standard Cayley graph of $\mathbb{Z}$ satisfies strict monotonicity with respect to variability, as does any Cayley graph of $F \rtimes F_k$, $F$ a nontrivial finite group and $F_k$ a free group. Moreover, it is proven that for graphs of strict polynomial growth and bounded degree graphs quasi-isometric to trees, if the weight measure is subcritical in an appropriate sense, then it is "absolutely continuous with respect to the expected empirical measure of the geodesic." This implies a strict monotonicity theorem with respect to stochastic domination of measures, whether or not the graph admits detours.