We explain the relation between certain random tiling models and interacting particle systems belonging to the anisotropic KPZ (Kardar-Parisi-Zhang) universality class in 2+1-dimensions. The link between these two \emph{a priori} disjoint sets of models is a consequence of the presence of shuffling algorithms that generate random tilings under consideration. To see the precise connection, we represent both a random tiling and the corresponding particle system through a set of non-intersecting lines, whose dynamics is induced by the shuffling algorithm or the particle dynamics. The resulting class of measures on line ensembles also fits into the framework of the Schur processes.