We study the quasi-ergodicity of compact strong Feller semigroups $U_t$, $t > 0$, on $L^2(M,μ)$; we assume that $M$ is a locally compact Polish space equipped with a locally finite Borel measue $μ$. The operators $U_t$ are ultracontractive and positivity preserving, but not necessarily self-adjoint or normal. We are mainly interested in those cases where the measure $μ$ is infinite and the semigroup is not intrinsically ultracontractive. We relate quasi-ergodicity on $L^p(M,μ)$ and uniqueness of the quasi-stationary measure with the finiteness of the heat content of the semigroup (for large values of $t$) and with the progressive uniform ground state domination property. The latter property is equivalent to a variant of quasi-ergodicity which progressively propagates in space as $t \uparrow \infty$; the propagation rate is determined by the decay of $U_t \mathbb{1}_M(x)$. We discuss several applications and illustrate our results with examples. This includes a complete description of quasi-ergodicity for a large class of semigroups corresponding to non-local Schrödinger operators with confining potentials.