In this paper we study a first extension of the theory of mild solutions for HJB equations in Hilbert spaces to the case when the domain is not the whole space. More precisely, we consider a half-space as domain, and a semilinear Hamilton-Jacobi-Bellman (HJB) equation. Our main goal is to establish the existence and the uniqueness of solutions to such HJB equations, that are continuously differentiable in the space variable. We also provide an application of our results to an exit time optimal control problem and we show that the corresponding value function is the unique solution to a semilinear HJB equation, possessing sufficient regularity to express the optimal control in feedback form. Finally, we give an illustrative example.