We study the existence, uniqueness, and regularity of the solution to the stochastic reaction-diffusion equation (SRDE) with colored noise $\dot{F}$: $$ \partial_t u = a^{ij}u_{x^ix^j} + b^i u_{x^i} + cu - \bar{b} u^{1+β} + ξu^{1+γ}\dot F,\quad (t,x)\in \mathbb{R}_+\times\mathbb{R}^d; \quad u(0,\cdot) = u_0, $$ where $a^{ij},b^i,c, \bar{b}$ and $ξ$ are $C^2$ or $L_\infty$ bounded random coefficients. Here $β>0$ denotes the degree of the strong dissipativity and $γ>0$ represents the degree of stochastic force. Under the reinforced Dalang's condition on $\dot{F}$, we show the well-posedness of the SRDE provided $γ< \frac{κ(β+1)}{d+2}$ where $κ>0$ is the constant related to $\dot F$. Our result assures that strong dissipativity prevents the solution from blowing up. Moreover, we provide the maximal Hölder regularity of the solution in time and space.