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math.PR updates on arXiv.org

Visibility in the Boolean Model on Harmonic Manifolds Global estimates on the Brenier map Geodesics and Wandering Exponents in Brochette First-Passage Percolation State-dependent inverse-subordinator time changes of regenerative processes: Excursion structure and multiscale occupation-time limits Randomly twisted transfer operators and singular values statistics Generalized Bessel-Dunkl diffusions An almost sure invariance principle for the Takagi-van der Waerden class functions Central limit theorems for high dimensional lattice polytopes: cosmological polytopes Convergence rate estimates for semigroups and heat kernels associated with resistance forms Second-order Poincaré inequalities and localization on the Poisson space Maximum Probability of Independence in Transitive Matroids On global solutions to the semidiscrete stochastic heat equation The Poisson Tail Conjecture for primes in short intervals A Complete Spectral Analysis of the CEV Operator with Applications to Arbitrage Holographic functions and neural networks From Betting to Empirical Bernstein LIL Concentration of General Stochastic Approximation Under Heavy-Tailed Markovian Noise Pointwise Generalization in Deep Neural Networks Bayesian Latent Space Models for Graphs Are Misspecified: Toward Robust Inference via Generalized Posteriors Wasserstein bounds for denoising diffusion probabilistic models via the Föllmer process A note on connections between the Föllmer process and the denoising diffusion probabilistic model Simple Approximation and Derivative Free Inference-Time Scaling for Diffusion Models via Sequential Monte Carlo on Path Measures Diffusion-Based Stochastic Operator Networks for Uncertainty Quantification in Stochastic Partial Differential Equations A Fourier perspective on the learning dynamics of neural networks: from sample complexities to mechanistic insights Propagation of Chaos in Contextual Flow Maps Dimension-Uniform Discretization Analysis of Preconditioned Annealed Langevin Dynamics for Multimodal Gaussian Mixtures $α$-TCAV: A Unified Framework for Testing with Concept Activation Vectors Scaling Laws from Sequential Feature Recovery: A Solvable Hierarchical Model On the Limits of Latent Reuse in Diffusion Models State-of-art minibatches via novel DPP kernels: discretization, wavelets, and rough objectives
Jump stochastic differential equations for the characteri...
Alastair Crossley, Karen Habermann, Emma Horton, Jere Koskela, A · 2024-09-11 · via math.PR updates on arXiv.org

Proton beam radiotherapy stands at the forefront of precision cancer treatment, leveraging the unique physical interactions of proton beams with human tissue to deliver minimal dose upon entry and deposit the therapeutic dose precisely at the so-called Bragg peak, with no residual dose beyond this point. The Bragg peak is the characteristic maximum that occurs when plotting the curve describing the rate of energy deposition along the length of the proton beam. Moreover, as a natural phenomenon, it is caused by an increase in the rate of nuclear interactions of protons as their energy decreases. From an analytical perspective, Bortfeld proposed a parametric family of curves that can be accurately calibrated to data replicating the Bragg peak in one dimension. We build, from first principles, the very first mathematical model describing the energy deposition of protons. Our approach uses stochastic differential equations and affords us the luxury of defining the natural analogue of the Bragg curve in two or three dimensions. This work is purely theoretical and provides a new mathematical framework which is capable of encompassing models built using Geant4 Monte Carlo, at one extreme, to pencil beam calculations with Bortfeld curves at the other.