Let $E$ be the class of finite (resp. probability) measures absolutely continuous with respect to a $σ$-finite Radon measure on a Polish space. We present a criterion on the quasi-regularity of Dirichlet forms on $E$ in terms of upper bound conditions given by the uniform $(L^1+L^\infty)$-norm of the extrinsic derivative. As applications, we construct a class of general type Markov processes on $E$ via quasi-regular Dirichlet forms containing the diffusion, jump and killing terms. Moreover, stochastic extrinsic derivative flows on $E$ are studied by using quasi-regular Dirichlet forms, which in particular provide martingale solutions to SDEs on these two spaces, with drifts given by the extrinsic derivative of entropy functionals.