The restricted hypercube-like graphs, variants of the hypercube, were proposed as desired interconnection networks of parallel systems. The matching preclusion number of a graph is the minimum number of edges whose deletion results in the graph with neither perfect matchings nor almost perfect matchings. The fractional perfect matching preclusion and fractional strong perfect matching preclusion are generalizations of the concept matching preclusion. In this paper, we obtain fractional matching preclusion number and fractional strong matching preclusion numbers of restricted hypercube-like graphs, which extend some known results.