We conduct a systematic study of the Ehrhart theory of certain slices of rectangular prisms. Our polytopes are generalizations of the hypersimplex and are contained in the larger class of polypositroids introduced by Lam and Postnikov; moreover, they coincide with polymatroids satisfying the strong exchange property up to an affinity. We give a combinatorial formula for all the Ehrhart coefficients in terms of the number of weighted permutations satisfying certain compatibility properties. This result proves that all these polytopes are Ehrhart positive. Additionally, via an extension of a result by Early and Kim, we give a combinatorial interpretation for all the coefficients of the $h^*$-polynomial. All of our results provide a combinatorial understanding of the Hilbert functions and the $h$-vectors of all algebras of Veronese type, a problem that had remained elusive up to this point. A variety of applications are discussed, including expressions for the volumes of these slices of prisms as weighted combinations of Eulerian numbers; some extensions of Laplace's result on the combinatorial interpretation of the volume of the hypersimplex; a multivariate generalization of the flag Eulerian numbers and refinements; and a short proof of the Ehrhart positivity of the independence polytope of all uniform matroids.