Fuglede's conjecture states that for a subset $Ω$ of a locally compact abelian group $G$ with positive and finite Haar measure, there exists a subset of the dual group of $G$ which is an orthogonal basis of $L^{2}(Ω)$ if and only if it tiles the group by translation. In this paper, we prove a divisibility property for a set in $\mathbb{Z}_{p}\times\mathbb{Z}_{p^{n}}$. Then using the divisibility property and equi-distributed property, we prove that Fuglede's conjecture holds in the group $\mathbb{Z}_{p}\times\mathbb{Z}_{p^{n}}$.