The study of universal derivations for arbitrary multiarrangements and multiplicity functions was initiated by Abe, Röhrle, Stump, and Yoshinaga in 2024 which focused on arrangements arising from (well-generated) reflection groups. In this paper we provide a criterion for determining whether a derivation is universal along with a characterization of universal derivations for arbitrary 2-multiarrangements. As an application we give descriptions of universal derivations for several multiarrangements, including the so-called deleted $A_3$ arrangement. This is the first known example of a non-reflection arrangement that admits a universal derivation distinct from the Euler derivation.