This paper investigates the nonexistence of solutions to semilinear parabolic and hyperbolic inequalities with positive potentials on metric graphs, including both nonnegative solutions and sign-changing solutions. The Laplacian under consideration is of a nonstandard type, incorporating contributions from both the vertices and edges of the metric graph. We construct a new pseudo-metric and introduce suitable space-time test functions of either coupled or separated type. Under suitable weighted space-time volume growth conditions on the potential, we establish nonexistence results for very weak solutions. More precisely, we show that all such solutions to the inequality must be identically zero.