In this paper, an upper bound for the perfect Italian domination number of the cartesian product of any two graphs is obtained and the exact value of this parameter for cartesian product of some special graphs are obtained. We have also proved that for any two positive integers $a$, $b$ there exists a graph $G$ and an induced subgraph $H$ of $G$ such that $γ_I^p(G) = a$ and $γ_I^p(H) = b$. Relationship of the perfect Italian domination number with the Roman domination number and the perfect domination number of a graph $G$ are obtained and the corresponding realization problems are also solved. We have also obtained the perfect Italian domination number of the Mycielskian of a graph in terms of the perfect domination number of the graph. Some open problems related to this parameters are also included.