This paper concerns frames and equiangular lines over finite fields. We find a necessary and sufficient condition for systems of equiangular lines over finite fields to be equiangular tight frames (ETFs). As is the case over subfields of $\mathbb{C}$, it is necessary for the Welch bound to be saturated, but there is an additional condition required involving sums of triple products. We also prove that similar to the case over $\mathbb{C}$, collections of vectors are similar to a regular simplex essentially when the triple products of their scalar products satisfy a certain property. Finally, we investigate switching equivalence classes of frames and systems of lines focusing on systems of equiangular lines in finite orthogonal geometries with maximal incoherent sets, drawing connections to combinatorial design theory.