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Complement Submodular Information Measures for Balanced and Robust Data Selection A Proof of a Conjecture on Positive and Negative Square Energies of Unicyclic Graphs Laplacian Spectrum of the Weakly Zero-Divisor Graph of a Finite Commutative Ring An identity for second Eulerian numbers via lattice-point counting $t$-tone edge coloring of graphs Constructing Maximal Bumpless Pipedreams for Double Grothendieck Polynomials Mubayi's Polynomial-Ideal Conjecture and Cover-Ideal Turán Methods Implicit Binarization via Complex Phase Dynamics in Combinatorial Optimization The limits of Schur multipliers in Pólya conversion problems for the $q$-permanent function Universality theorems for generalized splines Framing Triangulations for Arbitrary Integer Flow Polytopes On the Common Generalization of Gentle Algebras and Framed Directed Acyclic Graphs The complexity of frugal digraph homomorphisms Chaotic and periodic behavior of jeu de taquin on infinite Young tableaux Enumerating Pattern Avoiding Parking Functions Incidence toric ideals and three-point functions Unique Winning Opening Move in Three-Row Chomp Strong majority colorings of graphs A Balancing Theorem for Spanning Trees of Rectangular Grid Graphs Spectral radius and edge-disjoint connected factors of graphs New invariants for rank metric codes, with applications to the classification of rank two semifields of order 256 Flexible DP-4-coloring of planar graphs without 4-cycles and intersecting triangles Balanced intersection size distributions in projective planes List Reconstruction Problem with List Size Two Is Dimensionality a Barrier for Retrieval Models? The INIEP: Irreducible and Positive Realizations The number of Pfaffian orientations on punctured polygonally cellulated surfaces Explicit Construction of Polytopes whose Ehrhart Polynomials Realize any Given Sign Pattern Finite-state enumeration of adjacency-constrained 132-avoiding permutations AMDS and quantum AMDS Constacyclic codes of length $4p^ς$ over $\mathbb{F}_{{p}^{m}}$
Complexity of Modification Problems for Reciprocal Best M...
Marc Hellmuth, Manuela Geiß, Peter F. Stadler · 2019-07-21 · via math.CO updates on arXiv.org

Reciprocal best match graphs (RBMGs) are vertex colored graphs whose vertices represent genes and the colors the species where the genes reside. Edges identify pairs of genes that are most closely related with respect to an underlying evolutionary tree. In practical applications this tree is unknown and the edges of the RBMGs are inferred by quantifying sequence similarity. Due to noise in the data, these empirically determined graphs in general violate the condition of being a ``biologically feasible'' RBMG. Therefore, it is of practical interest in computational biology to correct the initial estimate. Here we consider deletion (remove at most $k$ edges) and editing (add or delete at most $k$ edges) problems. We show that the decision version of the deletion and editing problem to obtain RBMGs from vertex colored graphs is NP-hard. Using known results for the so-called bicluster editing, we show that the RBMG editing problem for $2$-colored graphs is fixed-parameter tractable. A restricted class of RBMGs appears in the context of orthology detection. These are cographs with a specific type of vertex coloring known as hierarchical coloring. We show that the decision problem of modifying a vertex-colored graph (either by edge-deletion or editing) into an RBMG with cograph structure or, equivalently, to an hierarchically colored cograph is NP-complete.