The existence of Hamiltonian cycles in 1-planar graphs with higher connectivity has attracted considerable attention. Recently, the authors and Dong proved that 4-connected 1-planar chordal graphs are Hamiltonian-connected. In this paper, we investigate the non-Hamiltonicity of a broader class of graphs, specifically perfect graphs, under the constraint of 1-planarity, with a focus on connectivity of at most 5. We also propose some unsolved problems.