An old and well-known conjecture of Frankl and Füredi states that the Lagrangian of an $r$-uniform hypergraph with $m$ edges is maximised by an initial segment of colex. In this paper we disprove this conjecture by finding an infinite family of counterexamples for all $r \ge 4$. We also show that, for sufficiently large $t \in \mathbb{N}$, the conjecture is true in the range $\binom{t}{r} \le m \le \binom{t+1}{r} - \binom{t-1}{r-2}$.