Symmetric edge polytopes are a class of lattice polytopes constructed from finite simple graphs. In the present paper we highlight their connections to the Kuramoto synchronization model in physics -- where they are called adjacency polytopes -- and to Kantorovich--Rubinstein polytopes from finite metric space theory. Each of these connections motivates the study of symmetric edge polytopes of particular classes of graphs. We focus on such classes and apply algebraic-combinatorial methods to investigate invariants of the associated symmetric edge polytopes.